Change of temperature causes whole body reprogramming

Rigomo Team

Sat, 04 Oct 2025

Human beings, like most of the organisms, are perpetually exposed to alternating colder or hotter temperatures. These environmental variations cause putting metabolic effects and wish constant variations. whereas variety of those variations confer sure helpful effects on health, the impact of cold and warmth on the various organs in AN extremely whole-body context wasn't proverbial. to grasp the biological mechanism at stake, a team from the University of Geneva (UNIGE) analyzed changes in natural phenomenon at the same time in varied organs in mice.

They found that each one organs powerfully react to temperature changes, every showing its own specific modulation. To stimulate analysis and potential therapeutic applications, the scientists created a web-based application wherever thousands of natural phenomenon profiles are freely accessible. These results is scan at intervals the journal life.

To address this aim, the scientists analyzed the expression of genes in eleven organs (all fatty (fat) tissues, muscle, liver, brain, neural structure, ileum, anatomical structure, spleen and bone marrow) of 3 teams of mice exposed to a temperature of 10°C, 22°C, or 34°C. "The knowledge show that the whole body deeply reacts to temperature changes," says Mirko Trajkovski.